1 minute treatment update
Treatment pearls in your chosen speciality or topic, as they are published, updated every 48 hours.
Last updated on 2023/11/28.
Nail lichen planus treatment safety.
Topical therapies for nail lichen planus (clobetasol propionate, topical tacrolimus, bath-PUVA), intralesional treatment (triamcinolone), and systemic treatment (corticosteroids, retinoids, small molecule inhibitors (jak/stat inhibitors), TNF-alpha inhibitors (etanercept), systemic immunomodulators (oral calcineurin inhibitors, mycophenolate mophetil), and antimalarials (chloroquine), each with unique safety profiles and considerations. Herein, we discuss common and uncommon adverse events, as well as utilization for special populations, including pregnant and pediatric patients
Long-term maintenance treatment of rosacea: experts' opinion.
Maintenance phase success depends on patient's adherence to daily skin care, appropriate treatments, continued follow-up with dermatologist, and self-assessment to identify new signs and symptoms indicating disease relapse.
Treatment of periorbital aging with negative pressure fractional microneedle radiofrequency: A self-controlled clinical trial.
NPMFR could be an effective and safe treatment modality for the treatment of periorbital aging.
B Cell-Directed Therapy in Autoimmunity.
annualreviews.org/page/journal/pubdates for revised estimates
Personalized neoantigen-based T cell therapy triggers cytotoxic lymphocytes expressing polyclonal TCR against metastatic ovarian cancer.
Notably, the neoantigen-specific TCR clonotypes persisted in the peripheral blood after cell therapy. Our findings indicate that personalized neoantigen-based T cell therapy triggers cytotoxic lymphocytes expressing polyclonal TCR against ovarian cancer, suggesting its promising potential in cancer immunotherapy
The Risk of Herpes Virus Infection in Patients With Atopic Dermatitis During Biologic Therapy: A Retrospective Records Based Observational Study.
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Safety and Efficacy of Dual TYK2 Inhibitor and Monoclonal Antibody Therapy for Psoriasis and Psoriatic Arthritis.
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Exacerbation of clinical manifestations of bullous pemphigoid after treatment with dupilumab.
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An 8-year follow-up of IgG4-related skin disease presented with generalized ALHE-like eruptions: successful treatment of glucocorticoid and cyclophosphamide.
He was treated with oral glucocorticoid and cyclophosphamide, which resulted in complete remission. No relapse and disease progression were seen with a follow-up for 8 years
A center-based, ambulatory care concept for hidradenitis suppurativa improves patient outcomes and is also cost-effectiveness.
Treatment costs of HS are substantial and increase with disease severity. The new form of care is cost-effective and is expected to decrease costs in the long run.
Associating personal and cultural reflections of identity with mental health status may cause more harm than help: a response to previous publication.
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A comprehensive review of nondermatophyte mould onychomycosis: Epidemiology, diagnosis and management.
Terbinafine and itraconazole therapy (continuous and pulsed) appear effective to varying extents for treating onychomycosis caused by Aspergillus, Fusarium or Scopulariopsis. There is scant literature on oral treatments for Neoscytalidium
New treatment of pyoderma gangrenosum and hidradenitis suppurativa: A review.
When resistance to biologics emerges, a combined approach targeting multiple overactive cytokines with immunosuppressants, for example cyclosporine and Janus kinase inhibitors, could be an option. In the current review, we explore recent therapeutic developments for PG and HS
Pyoderma gangrenosum successfully treated with split-thickness skin grafting in combination with negative pressure wound therapy: A case report.
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Favorable efficacy of S-1 treatment for locoregionally advanced cutaneous squamous cell carcinoma in the head and neck region.
S-1 showed favorable efficacy and low toxicity in patients with head and neck locoregionally advanced cutaneous squamous cell carcinoma. S-1 may be a good alternative to the anti-PD-1 antibody for treating head and neck locoregionally advanced squamous cell carcinoma
Management of severe allergy, reacting to acetaminophen and small doses of cyclooxygenase-2 inhibitor.
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Pulsed-dye laser as an effective treatment for recalcitrant granulomatous rosacea and a potential regulator of CXCL9 expression.
These findings suggest that PDL may modulate CXCL9 secretion in fibroblasts, potentially limiting the recruitment of immune cells to the lesion. Although further research is needed to fully understand the precise mechanisms underlying the role of CXCL9 in GR, PDL may be a promising therapeutic approach for refractory GR
Clinical Evaluation of Liposome-based Gel Formulation Containing Glycolic Acid for the Treatment of Photodamaged Skin.
Moreover, liposomal gel formulation was able to minimize side effects of GA. According to the obtained results, the liposome-based gel formulation can be used as potential drug delivery system to enhance permeation of GA through skin layers and also reduce its side effects
Long-term remission with rituximab therapy in a five-year-old patient with pemphigus vulgaris.
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Facial segmental lipoatrophy effectively treated with a deep priming filler incorporating calcium hydroxyapatite with results sustained for 12 months.
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