Treatment pearls in your chosen speciality or topic, as they are published, updated every 48 hours.
Last updated on 2021/07/29.
Omalizumab shows promise as a potential therapy for mast cell disorders; however, its efficacy in TMEP is yet to be established. This case describes a 72-year-old woman with chronic refractory TMEP achieving symptomatic remission within 4 months of commencing omalizumab therapy
In this patient, a marked improvement in both hyperhidrosis and facial erythema was noted with this combined therapy. We consider it of interest to highlight the response of our patient to the treatment employed, which may be advantageous in future cases of this rare disorder
In this review, we have outlined the present understanding of the immunological response of NK cells in COVID-19 infection. We have also discussed the possible use of these powerful biological cells as a therapeutic agent in view of preventing immunological harms of SARS-CoV-2 and the current challenges in advocating NK cell therapy for the same
Complex, supervised rehabilitation improves hand and overall function in SSc patients up to 6 months after the treatment but not in the long term. The regular repetition of this rehabilitation program should be recommended every 3-6 months to maintain better hand and overall function
TNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a "risk-adapted," multi-disciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin-directed therapies is preferred, as both disease-specific and overall survival for these patients is favorable. In contrast, patients with advanced-stage disease with significant nodal, visceral or blood involvement are generally approached with systemic therapies, including biologic-response modifiers, histone deacetylase inhibitors, or antibody-based strategies, in an escalating fashion. In highly-selected patients, allogeneic stem-cell transplantation may be considered, as this may be curative in some patients. This article is protected by copyright. All rights reserved.
In light of the discontinuation of ESKATA in late 2019, promising alternatives, such as nitric-zinc and trichloroacetic acid topicals, should be further developed. There is also a need for larger, head-to-head trials of emerging laser therapies to ensure that future treatment standards address diverse patient needs
First approved vaccines against SARS-COV-2 (mRNA-1273 and BNT162b2) consists of Messenger Ribonucleic Acid (mRNA), encoding the SARS-CoV-2 spike protein, that penetrate cells and produce spike protein . In these vaccines' clinical trials, chilblain-like lesions were not reported ; however, the World Health Organization warned of the possible of appearance of chilblain-like lesions during SARS-CoV-2 vaccination campaign
Methotrexate (MTX), a folic acid reductase inhibitor, is prescribed as the first-line systemic treatment for patients with psoriasis. Although the therapeutic efficacy of MTX has been well demonstrated, patients show substantial heterogeneity in their response to MTX therapies, and the efficacy of MTX in a given patient is unpredictable
Its high transmission capacity coupled with the lack of effective treatment led to the rapid development of vaccines that today, have been administered in a wide list of countries. As a result, new post-vaccination adverse events continue to be described
Thus, prognostic and predictive biomarkers including metabolic host factors are needed. The modified Glasgow-prognostic-score (mGPS) is a well-established immuno-nutritional prognostic assessment in various cancers(5-8), but not yet assessed in melanoma
In Hidradenitis Suppurativa (HS), the identification of disease activity biomarkers is a key priority . Sonographic-based imaging biomarkers have been established as valid measurements of baseline disease activity , however the response of epidermal thickness, tunnel diameter and power Doppler intensity in the setting of pharmacologic therapy is unknown