1 minute treatment update

Treatment pearls in your chosen speciality or topic, as they are published, updated every 48 hours.
Last updated on 2021/10/24.





Curr Opin Pediatr 19 Oct. 2021.
Cutaneous coronavirus disease 2019 in children: a clinical primer for diagnosis and treatment.

There are ongoing worldwide registries, clinical and basic science studies to better understand the burden of skin disease and pathophysiology of rashes seen in patients infected with COVID-19. Robust vaccination programs should be encouraged as a way to contain viral spread among children and the greater population.

 Pubmed Scholar sci-hub

Photodiagnosis Photodyn Ther 17 Oct. 2021.
Mechanism of a new photosensitizer (TBZPy) in the treatment of high-risk human papillomavirus-related diseases.

Our study demonstrates the effectiveness of TBZPy-PDT against human papillomavirus-related diseases. These findings provide a foundation for using this novel photosensitizer to treat diseases associated with high-risk human papillomavirus infection.

 Pubmed Scholar sci-hub

Dermatol Ther (Heidelb) 20 Oct. 2021.
Effects of Sonidegib Following Dose Reduction and Treatment Interruption in Patients with Advanced Basal Cell Carcinoma During 42-Month BOLT Trial.

ClinicalTrials.gov identifier, NCT01327053.

 Pubmed Scholar sci-hub

Microbiol Spectr 20 Oct. 2021.
Array

Combinations of gentamicin plus ertapenem, ceftriaxone, and azithromycin produced synergistic effects against certain MDR isolates. No antagonism was observed in any of the antimicrobial combinations, which may prove useful to guide clinical testing of combination therapies

 Pubmed Scholar sci-hub

J Eur Acad Dermatol Venereol Nov. 2021.
Current controversies in trichology: a European expert consensus statement.

All recommendations reached consensus after the two-round Delphi questionnaire and may be useful in clinical practice for dermatologists. The participants agreed that besides this consensus, further clinical studies are needed to assess the benefits of the emerging tools and treatments and to clarify the controversies that still exist in the field, aiming at improving patients' quality of life.

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Indian Dermatol Online J . .
The Adverse Cutaneous Effects of Hand Hygiene Practices among Individuals Other than Non-Healthcare Providers During Coronavirus-19 Pandemic: A Cross-Sectional Online Survey.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

Indian Dermatol Online J . .
Clinico-Mycological Profile of Treatment-Naïve, Chronic, Recurrent and Steroid-Modified Dermatophytosis at a Tertiary Care Centre in Eastern India: An Institution-Based Cross-SectionalStudy.

Among 111 patients,(F: M 1.7:1; mean age 44.4 ± 18.2 years), 51.4% were treatment naïve, while 34.2% and 14.4% presented with chronic and recurrent tinea respectively. Family history and sharing of fomites among infected family members was commoner in the latter groups ( = 0.001). Topical steroid application was reported in 49.5%, however only 7.2% presented with steroid modified tinea. Tinea corporis et cruris (41.4%) was the predominant clinical type followed by tinea corporis (34.2%) and tinea cruris (27.9%). KOH mount and culture were positive in 62.2% and 39.6% cases respectively; commonest isolates being , and complex in 15.3% cases each. was the commonest etiology for treatment naïve and recurrent cases, while was the commonest isolate from chronic and steroid-modified cases ( = 0.0003). Interestingly, complex and were the commonest causes of tinea corporis and tinea cruris respectively ( = 0.07).

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Indian Dermatol Online J . .
Efficacy of NB-UVB in Progressive Versus Non-Progressive Non-Segmental Vitiligo: A Prospective Comparative Study.

NB-UVB has the potential to halt disease progression in some patients with progressive vitiligo; but is associated with more total NB-UVB fluence and time taken for fixing it. Progressive vitiligo patients have more pruritus as compared to patients with non-progressive vitiligo.

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Indian Dermatol Online J . .
A Cross-Sectional Study to Correlate Disease Severity in Bullous Pemphigoid Patients with Serum Levels of Autoantibodies Against BP180 and BP230.

BP antibody titers correlate partially with disease severity. Anti-BP180 antibody is associated with more severe disease. Anti-BP230 antibody titer does not correlate with disease severity.

 Pubmed Scholar sci-hub

Indian Dermatol Online J . .
Systemic Management of Psoriasis Patients in Indian Scenario: An Expert Consensus.

These recommendations are meant to provide guidance in terms of choice of systemic therapies, dosing, effectiveness, and safety. It also addresses clinical challenges that may be experienced during psoriasis management.

 Pubmed Scholar sci-hub

Plast Reconstr Surg Glob Open Aug. 2021.
A Case of Scapular Hidradenoma Treated as a Keloid.

Thus, hidradenoma should be taken in consideration as a differential diagnosis when encountering steroid-refractory keloid-like lesions. Moreover, early biopsy or surgical resection should be considered

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Sci Rep 19 Oct. 2021.
K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors.

Furthermore, moderate enforced expression of NKIRAS2 augmented oncogenic HRAS-provoked cellular transformation, whereas an excess NKIRAS2 expression converted its functional role into a tumor suppressive phenotype, suggesting that NKIRAS seemed to exhibit a biphasic bell-shaped enhancing effect on HRAS-mutant-provoked oncogenic activity. Taken together, the functional role of NKIRAS in carcinogenesis is most likely determined by not only cellular context but also its expression level

 Pubmed Scholar sci-hub

Diagn Interv Imaging 16 Oct. 2021.
CT texture analysis as a predictor of favorable response to anti-PD1 monoclonal antibodies in metastatic skin melanoma.

Pretreatment CT texture analysis-derived tumor skewness and variation of entropy between baseline and first control CT examination may be used as predictors of favorable response to anti-PD1 monoclonal antibodies in patients with metastatic SM.

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Bioengineered 20 Oct. 2021.
Curcumin protection against ultraviolet-induced photo-damage in Hacat cells by regulating nuclear factor erythroid 2-related factor 2.

While in the Nrf2 knockdown cells, the protective effects of curcumin against UVA (or UVB) were attenuated. Conclusively, curcumin protects Hacat cells against UV exposure-induced photo-damage by regulating Nrf2 expression

 Pubmed Scholar sci-hub

World J Mens Health 13 Oct. 2021.
Sperm Vitality and Necrozoospermia: Diagnosis, Management, and Results of a Global Survey of Clinical Practice.

In this study, we report the results of a global survey to understand current practices regarding the physician order of sperm vitality tests as well as the management practices for necrozoospermia. Laboratory and clinical scenarios are presented to guide the reader in the management of necrozoospermia with the overall objective of establishing a benchmark ranging from the diagnosis of necrozoospermia by sperm vitality testing to its clinical management

 Pubmed Scholar sci-hub

J Appl Toxicol 19 Oct. 2021.
Efficacy of water-only or soap and water skin decontamination of chemical warfare agents or simulants using in vitro human models: A systematic review.

Pending manuscripts will summarize in vivo human and animal efficacy data. International harmonized efficacy protocol should enable more efficient public health decisions for evidence-based public health decisions

 Pubmed Scholar sci-hub

Australas J Dermatol 19 Oct. 2021.
Hyperkeratotic flexural erythema and response to amoxicillin-clavulanic acid: Two cases within the same family.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

Dermatol Ther 19 Oct. 2021.
Cannabinoids interaction with transient receptor potential family and implications in the treatment of rosacea.

This article is protected by copyright. All rights reserved

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J Cosmet Dermatol 19 Oct. 2021.
Efficacy of combined fractional carbon dioxide laser and topical tazarotene in nail psoriasis treatment: A randomized intrapatient left-to-right study.

Fractional CO  laser is an effective and well-tolerated treatment for nail psoriasis; it improves the outcomes of topical tazarotene especially in nail bed lesions.

 Pubmed Scholar sci-hub

Health Qual Life Outcomes 18 Oct. 2021.
Evaluating health related quality of life in outpatients receiving anti-cancer treatment: results from an observational, cross-sectional study.

In our study, the neoplastic disease and anti-cancer treatment toxicities had an impact on HRQOL. Patients had poorer scores in the functional well-being domain and higher ones in the social/family well-being domain. Variables associated with worse HRQOL were tumor stage, performance status (ECOG) and female sex.

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