1 minute treatment update

Treatment pearls in your chosen speciality or topic, as they are published, updated every 48 hours.
Last updated on 2022/08/09.





Biochim Biophys Acta Mol Basis Dis 05 Aug. 2022.
Differential RNA expression of immune-related genes and tumor cell proximity from intratumoral M1 macrophages in acral lentiginous melanomas treated with PD-1 blockade.

The spatial distributions of PD-1+ T-cells and activated M1 macrophages showed a significant correlation with favorable responses to ICIs. Our findings highlight the clinical relevance of the spatial proximity of immune cell subsets in the treatment outcomes of metastatic malignant melanoma

 Pubmed Scholar sci-hub

J Am Acad Dermatol 05 Aug. 2022.
A retrospective case series of 20 patients with immunotherapy-induced bullous pemphigoid with emphasis on management outcomes.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

Australas J Dermatol 08 Aug. 2022.
Immediate possible adverse event rates in infants treated with oral propranolol for infantile haemangiomas at an Australian urban tertiary hospital between 2016 and 2019.

Propranolol is a safe, effective and well-tolerated treatment in Australian children with IH. This study demonstrates younger infants will most likely benefit from inpatient initiation. More research needs to be done to characterise the risk profile of propranolol initiation for IH.

 Pubmed Scholar sci-hub

Front Surg . 2022.
Ferroptosis-related lncRNA signature predicts prognosis and immunotherapy efficacy in cutaneous melanoma.

Our novel ferroptosis-related lncRNA signature was able to accurately predict the prognosis and ICI outcomes of CM patients. These ferroptosis-related lncRNAs might be potential biomarkers and therapeutic targets for CM.

 Pubmed Scholar sci-hub

Biomed Res Int . 2022.
Cognition/Psychological Burden and Resilience in Cutaneous T-Cell Lymphoma and Psoriasis Patients: Real-Life Data and Implications for the Treatment.

Memory impairment may be associated comorbidity in CTCL and psoriasis. Subjects with stronger cognitive resources appear to cope better with health-related quality of life (HR-QOL) challenges.

 Pubmed Scholar sci-hub

Biomed Res Int . 2022.
Clinical Effect of Microneedle Injection Combined with Blood Transfusion in the Treatment of Severe Anemia Complicated with Vitiligo under Regenerative Medical Technology.

To sum up, based on regenerative medical technology, microneedle injection (microneedling is a derma roller process that pricks the skin with minuscule needles. The goal of the treatment is to develop new collagen and skin tissue, resulting in skin that is smoother, firmer, and more toned) combined with blood transfusion had a good therapeutic effect on patients with severe anemia complicated with vitiligo, which could manifestly improve the blood indexes and skin plaques of patients, with a good clinical adoption effect

 Pubmed Scholar sci-hub

Comput Math Methods Med . 2022.
A Meta-analysis of Xiaoyin Granules Combined with Acitretin Capsule in the Treatment of Psoriasis Vulgaris.

The combination of Xiaoyin granule and acitretin capsules could be a novel therapeutic strategy in the treatment of psoriasis vulgaris. However, the quality of trials in this study limited the conclusion, and more high-quality RCTs are needed for further evaluation.

 Pubmed Scholar sci-hub

Front Immunol . 2022.
Hemidesmosomal Reactivity and Treatment Recommendations in Immune Checkpoint Inhibitor-Induced Bullous Pemphigoid-A Retrospective, Monocentric Study.

The disease can still be active after ICI discontinuation, while rituximab might be required for remission. Finally, four tumour samples were stained histochemically for collagen XVII (BP180), but no enhanced expression was found

 Pubmed Scholar sci-hub

Front Cardiovasc Med . 2022.
Predictors of restenosis following percutaneous coronary stent implantation: The role of trimetazidine therapy.

TMZ reduces the occurrence of ISR following PCI, with special effectiveness in BMS-implanted patients having CCS and narrow coronary arteries. TMZ treatment may help to lower ISR formation in countries with high BMS utilization rates.

 Pubmed Scholar sci-hub

Adv Pharm Bull May. 2022.
Combination Therapy of Metadichol Nanogel and Lipocalin-2 Engineered Mesenchymal Stem Cells Improve Wound Healing in Rat Model of Excision Injury.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

J Allergy Clin Immunol Aug. 2022.
Are blood cytokines reliable biomarkers of allergic disease diagnosis and treatment responses?

Among the variety of suggested cytokines, thymus and activation-regulated chemokine (TARC) stands out and can indeed serve as a biomarker of atopic dermatitis. Both biologic characteristics and technical issues determine the reliability and limit the use of blood cytokines as biomarkers

 Pubmed Scholar sci-hub

Int J Oral Maxillofac Surg 04 Aug. 2022.
Use of the high-dose pulsed hyaluronidase protocol in the management of impending skin necrosis associated with hyaluronic acid fillers: a systematic review.

Initiating the protocol within 24 h of filler injection halted the progression of necrosis and prevented permanent sequelae. The conclusions are limited by the lack of a high level of evidence, since the only available sources of data are case reports and case series

 Pubmed Scholar sci-hub

Facial Plast Surg Clin North Am Aug. 2022.
Treatment of Periorbital Vascularity, Erythema, and Hyperpigmentation.

Modalities vary from topical therapies, chemical peels, dermal fillers, and lasers, to surgical intervention. Because POH can be multifactorial, successful management of POH will depend on elucidating the etiology and often requires a combination of therapies

 Pubmed Scholar sci-hub

J Am Acad Dermatol 04 Aug. 2022.
Real-World Safety and Clinical Response of Janus Kinase Inhibitor Upadacitinib in the Treatment of Hidradenitis Suppurativa: A Retrospective Cohort Study.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

Int Arch Allergy Immunol 05 Aug. 2022.
Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice.

The present study showed that SDS treatment of ear skin in C57BL/6 mice induces mast cell-independent skin inflammation with H1-antihistamine-refractory itch and suggested a possible Th cytokine- and/or lymphocyte-mediated regulation of the model. The model would be useful for elucidation of mechanisms for inflammation with H1-antihistamine-refractory itch in detergent-induced ICD.

 Pubmed Scholar sci-hub

Int J Dermatol 07 Aug. 2022.
Janus kinase-signal transducers and activators of transcription (JAK-STAT) activation in anti-programmed death-1 (PD-1) therapy-Associated granuloma annulare: a case series.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

Int J Dermatol 07 Aug. 2022.
Secukinumab in the treatment of a child with congenital ichthyosiform erythroderma with ABCA12 mutation.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

Dermatol Ther (Heidelb) 07 Aug. 2022.
Durability of Response to Abrocitinib in Patients with Moderate-to-Severe Atopic Dermatitis After Treatment Discontinuation in a Phase 2b Trial.

ClinicalTrials.gov identifier NCT02780167.

 Pubmed Scholar sci-hub

J Am Acad Dermatol 03 Aug. 2022.
Comment on: Diagnostic Testing of Eczematous Dermatitis with Incomplete Response to Dupilumab.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

Ophthalmology 03 Aug. 2022.
Ophthalmologic involvement in adults with histiocytic disorders: Clinical presentation and treatment outcomes.

Orbital involvement was more commonly seen in LCH and ECD, while ocular involvement was more common in RDD. Visual acuity may be impacted from ocular involvement, or from compression of the optic nerve with diffuse orbital involvement.

 Pubmed Scholar sci-hub