1 minute treatment update
Treatment pearls in your chosen speciality or topic, as they are published, updated every 48 hours.
Last updated on 2024/07/27.
Therapeutic Anti-Tumor Efficacy of DC-Based Vaccines Targeting TME-Associated Antigens Is Improved When Combined with a Chemokine-Modulating Regimen and/or Anti-PD-L1.
Peptide-based vaccines that selectively target either melanoma antigens or TBVAs elicited a CD8 T cell repertoire recognizing both tumor cells and tumor-associated VECs and pericytes in vitro, consistent with a treatment-induced epitope spreading mechanism. Notably, combination vaccines including anti-PD-L1 + CKM yielded superior therapeutic effects on tumor growth and animal survival, in association with the potentiation of polyfunctional CD8 T cell reactivity against both tumor cells and tumor-associated vascular cells and a pro-inflammatory TME
Current Evidence and Future Perspectives in the Medical Management of Vascular Ehlers-Danlos Syndrome: Focus on Vascular Prevention.
Drugs targeting the extracellular matrix organization and autophagy-lysosome pathways are currently under investigation and could play a role in the future. This narrative review aims to summarize current evidence and future perspectives on vEDS medical treatment, with a specific focus on vascular prevention
Monoclonal Antibodies in the Management of Inflammation in Wound Healing: An Updated Literature Review.
However, due to the complex molecular nature of wound healing, no single target molecule can be identified. Therefore, the use of mAbs should be considered as a translational approach for limited cases of multi-resistant conditions
Lack of Serological Response by Delivery to Syphilis Treatment Does Not Impact Pregnancy Outcomes.
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Blood-Count-Derived Inflammatory Markers as Predictors of Response to Biologics and Small-Molecule Inhibitors in Psoriasis: A Multicenter Study.
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Drug Survival, Safety, and Effectiveness of Secukinumab for up to 5 Years in Patients with Psoriasis and Psoriatic Arthritis: A Long-Term Real-Life Experience.
Secukinumab showed effectiveness for up to 5 years of treatment, with a high DS and achievement of PASI100, PASI90, and PASI < 3 at these time points. Only obesity reduced the response and maintenance of DS.
Acute and Preventive Treatment of COVID-19-Related Headache: A Series of 100 Patients.
The most frequently used drug was amitriptyline, which obtained the best results. In some treatment-resistant patients, anesthetic blockades and onabotulinumtoxinA were also beneficial
Comparative Evaluation of Species-Specific T-Cell Immune Response in Human Peripheral Blood Mononuclear Cells.
This investigation holds the potential to advance our comprehension of the distinct immune responses induced by spp., with probable implications in designing antifungal immunotherapeutics
Advanced and Metastatic Non-Melanoma Skin Cancer: Epidemiology, Risk Factors, Clinical Features, and Treatment Options.
Programmed death receptor 1 antibody (PD-1) inhibitors such as cemiplimab, pembrolizumab, and nivolumab have been approved for the treatment of cSCC. Thus, this paper reviews the epidemiology, risk factors, clinical features, and treatment options for both BCC and cSCC
Management of Skin Toxicities in Cancer Treatment: An Australian/New Zealand Perspective.
This review provides details on twelve common dermatological toxicities encountered during cancer treatment and offers measures for their prevention and management, particularly in the Australian/New Zealand context where skincare requirements may differ to other regions due to higher cumulative sun damage caused by high ambient ultraviolet (UV) light exposure. Given the frequency of these dermatological toxicities, a proactive phase is envisaged where patients can actively try to prevent skin toxicities
Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment.
In addition, Dl treatment reduced ER stress and suppressed apoptosis. Our findings suggest that Dl specifically targets pathogenic mechanisms of DD and may be a potential treatment
International consensus on fasting terminology.
" "Intermittent fasting" (repetitive fasting periods lasting ≤48 h), "time-restricted eating," and "fasting-mimicking diet" were discussed most. This study provides expert recommendations on fasting terminology for future research and clinical applications, facilitating communication and cross-referencing in the field
Omalizumab in the treatment of bullous pemphigoid: A single-center series of 15 cases.
002). In this study, omalizumab treatment was an effective and safe option in BP patients with high baseline IgE levels who are refractory to or cannot tolerate other immunosuppressive therapies
Herpes Zoster and Post-Herpetic Neuralgia-Diagnosis, Treatment, and Vaccination Strategies.
This article serves as a guideline for clinicians in the diagnosis, investigations, management, and prevention of herpes zoster. With the majority of adults in Singapore currently at risk of developing herpes zoster due to varicella immunization being only introduced in 2020, it is important for clinicians to recognize and manage herpes zoster appropriately.
Janus Kinase Inhibitor Therapy for Cicatricial Alopecias: An Evidence-Based Review.
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Management of Cutaneous Dermatomyositis With Systemic Biologic Therapies: A Systematic Review.
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Association of Proton Pump Inhibitors on Psoriasis Treatment and Development: A Systematic Review.
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Visible Light in the Treatment of Acne Vulgaris.
This review highlights the potential of visible light therapy in acne treatment. Head-to-head studies are needed to compare the efficacy of visible light compared to existing therapies for the treatment of acne
Treatment Challenges in Alopecia Areata: Insights From a Case of Baricitinib Therapy Failure.
Clinical trials have shown promising results with baricitinib, and reports of relapse after initial success are scarce. We present a unique case of a 30-year-old male with severe patch-type AA who initially responded well to baricitinib treatment but later experienced a relapse despite continued treatment
Chlorhexidine gluconate for antisepsis in preterm neonates: A review of safety and efficacy.
Thus, there are few studies assessing the role of chlorhexidine gluconate in antisepsis for preterm neonates. A better understanding of the safety and efficacy of chlorhexidine gluconate as an antiseptic agent for preterm neonates is the first step in establishing best practice guidelines for this population