1 minute treatment update

Treatment pearls in your chosen speciality or topic, as they are published, updated every 48 hours.
Last updated on 2021/12/06.





Clin Exp Dermatol 04 Dec. 2021.
Gaining access to treatment; life at the far side of atopic eczema.

I spent a lot of my childhood & young adult life in "Hume Street" hospital, each admission would last 2 - 3 weeks at a time in a bid to get my eczema under control again. My entire life

 Pubmed Scholar sci-hub

J Dtsch Dermatol Ges 04 Dec. 2021.
Common diseases of the nail: Diagnosis and therapy.

They include onychomycoses, nail psoriasis, onychodystrophies, subungual hematoma, paronychia, ingrown nails and pincer nails. Due to the peculiar anatomy and physiological growth conditions of the nail, the pathology does not necessarily stem from the site of the clinical problem and calls for careful inspection and interpretation

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J Dermatol 03 Dec. 2021.
Clarithromycin for the treatment of pyoderma gangrenosum associated with myelodysplastic syndrome.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

J Dermatol 03 Dec. 2021.
Successful treatment of Netherton syndrome with dupilumab: A case report and review of the literature.

The clinical manifestation and dermoscopic images of the patient's hair showed remarkable improvement after dupilumab treatment with no adverse effects. We also reviewed previous reports to learn more about the therapeutic effect and adverse reactions of NS treated with dupilumab

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Clin Exp Dermatol 04 Dec. 2021.
Systemic minoxidil as maintenance treatment in alopecia areata: a retrospective case-series of 24 patients.

Relapse rates are low for patients with disease duration <6 months (13%), moderate for disease duration 6-12 months (65%) and high for disease duration ≥12 months (up to 100%). There is unmet need for safe and effective maintenance therapy that reduces the risk of AA relapse following initial regrowth

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Br J Dermatol 03 Dec. 2021.
The potential of gene therapy for recessive dystrophic epidermolysis bullosa.

Thus, there is an increasing need for the practising dermatologist to become familiar with the concept of gene therapy, fundamental differences between various approaches and their human applications. This review explains the principles of different approaches of gene therapy; summarises its journey and discusses its current and future impact in RDEB

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Skinmed . 2021.
Efficacy of Platelet-Rich Fibrin in the Treatment of Trophic Ulcer in Leprosy.

Ninety percent reduction in mean ulcer volume was seen at 6 weeks, with a mean healing time of 5 weeks. PRF is cost-effective, day care procedure with promising results in trophic ulcers

 Pubmed Scholar sci-hub

Skinmed . 2021.
Efficacy and Safety of Contact Cryosurgery in the Treatment of Earlobe Keloids.

Two patients had a transient hypopigmentation which disappeared 2 months after the final session of contact cryosurgery. The results of our study highly encourage the use of contact cryosurgery which has tolerable side effects and high safety

 Pubmed Scholar sci-hub

Mycoses 03 Dec. 2021.
In Vitro Activities of 8 Antifungal Agents against Geophilic Dermatophyte Isolates.

Luliconazole, terbinafine and efinaconazole exhibited the highest in vitro efficacy, regardless of the dermatophyte species. Further surveillance studies are recommended to confirm the implication of such in vitro data for the clinical recovery rate of dermatophytosis with geophilic species following antifungal therapy.

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CMAJ 14 Jun. 2021.
Actinic keratosis of the lower lip treated with photodynamic therapy.

Sorry! No treatment pearl could be fetched.

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Expert Opin Biol Ther 03 Dec. 2021.
Near-infrared photoimmunotherapy for the treatment of skin disorders.

NIR-PIT may be an attractive strategy for the treatment of skin disorders. The main advantage of NIR-PIT therapy is its low toxicity to healthy tissues. Cutaneous lymphocyte antigen is a potential molecular target for NIR-PIT for both cutaneous T-cell lymphomas and inflammatory skin disorders.

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J Cosmet Dermatol 03 Dec. 2021.
Comparison of teledermatological examinations with conventional office visits in management of acne vulgaris: A review of current literature.

In addition, the satisfaction of doctors, the main safety concerns of patients, and a brief insight into telemedicine in other specialties are discussed. Taking the results of the different studies into account, the conclusion is that telemedicine is well accepted and often even desired by most patients and will likely become a very important part of modern medicine in the future

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Dermatol Ther 03 Dec. 2021.
Treatment Of Chronic Venous Disorder: A Comprehensive Review.

Compression treatment is the mainstay of conservative treatment. Pharmacological treatment can provide significant symptomatic relief and hence it should be considered as part of conservative treament. Transcutaneous Lacer treatment (TCL) is an effective alternative option to sclerotherapy for treatment of C1 stage. Interventional treatment of saphenous insufficiency should not be withholded in favor of conservative treatment when indications for intervention are present. High ligation and stripping (HL/S), ultrasound-guided foam sclerotherepy (UGFS), endovenous thermal ablation (EVTA) systems and non thermal non tumescent ablation (NTNT) systems are safe and efficacious first-line options for treatment of saphenous insufficiency. Interventional treatment of co-existing incompetent perforator veins (IPVs) is not recommended by contemporary evidence. Regarding deep venous insufficiency (DVI), treatment of symptomatic femoroiliocaval occlussive venous disease refractory to conservative treatment with percutaneous transluminal venoplasty stenting produced encouraging results.

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Clin Exp Dermatol 03 Dec. 2021.
First use of the Adolescent Depression Rating Scale (ADRS) in the management of young people with severe acne treated with isotretinoin: A pilot study of an active monitoring of depressive disorders by dermatologists.

The implementation of the ADRS could be valuable in dermatology practice, optimising the monitoring of patients and the good use of isotretinoin.

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Lasers Surg Med 02 Dec. 2021.
Comparison of the efficacy and safety of 308-nm excimer laser with intralesional corticosteroids for the treatment of alopecia areata: A randomized controlled study.

The excimer laser was safe and effective in AA. The effect of laser on hair regrowth might be delayed as compared with ILCS.

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Front Bioeng Biotechnol . 2021.
Biocompatible Mesoporous Silica-Polydopamine Nanocomplexes as MR/Fluorescence Imaging Agent for Light-Activated Photothermal-Photodynamic Cancer Therapy .

Besides, the MSN-Ce6@PDA (Mn) nanocomplexes also exhibited excellent biocompatibility and low damage to the healthy animals. Hence, the results demonstrated that the prepared MSN-Ce6@PDA (Mn) nanocomplex would be a promising potential for multimodal imaging-guided phototherapy

 Pubmed Scholar sci-hub

Front Public Health . 2021.
Protocol for a Systematic Review on the Effectiveness of Interventions to Reduce Exposure to Occupational Solar UltraViolet Radiation (UVR) Among Outdoor Workers.

Sorry! No treatment pearl could be fetched.

 Pubmed Scholar sci-hub

Oncoimmunology . 2021.
Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival.

The identification of novel lung cancer HLA-associated epitopes that correlate with improved ICI-dependent treatment outcomes suggests that keratinocyte-specific proteins are important tumor-associated antigens in NSCLC. These findings improve our understanding of the mechanisms of ICI therapy and may help support the development of vaccination strategies to improve ICI-based treatment of these tumors

 Pubmed Scholar sci-hub

Int Med Case Rep J . 2021.
Chronic Venous Leg Ulcer in Klinefelter Syndrome Treated with Platelet-Rich Fibrin: A Case Report.

After 7 weeks of treatment with PRF, the ulcer almost reached complete closure. PRF gives a good result in a chronic VLU with KS

 Pubmed Scholar sci-hub

Clin Cosmet Investig Dermatol . 2021.
A Novel Itraconazole Pulse Therapy Schedule in the Treatment of Tinea Capitis in Children.

We demonstrate the efficacy and safety of this novel itraconazole pulse therapy schedule. It may be a promising therapy in the treatment of tinea capitis in children

 Pubmed Scholar sci-hub